Epidemics, Slavery, Massacres, and Indigenous Resistance 1492-1599


Calusa of Florida drive Ponce de Leon away

Juan Ponce de Leon
Juan Ponce de Leon

Ponce de Leon accompanies Columbus on his second voyage and by the time they arrive in Florida, Calusa tribal people and other southeastern Native communities have spread the word and alerted other communities of the brutality of the Spaniards. When Ponce de Leon arrives in the bay off the coast of the Calusa territory, over 80 war canoes drive him off (Nies, 1996).

Native Resistance